Microspheres as a promising mucoadhesive drug delivery system. Hollow microspheres are used as additives to lower the density of a material. Alginate was used as the core bead core polymer and chitosan as the mucoadhesive polymer coating. The pure drug such as clopidogrel was dissolved in 10 ml of water and mixed with the above polymer mixture. Applications of chitosan and chitosan derivatives in drug. The release of drug from both biodegradable as well as nonbiodegradable microspheres is influenced by structure or micromorphology of the carrier and the properties of the polymer itself. Here, we introduce the use of a novel excipient based on calcium carbonate fcc, omyapharm as a drug carrier and adsorption platform of chitosan. Chitosan is a mucoadhesive polysaccharide capable of opening the tight junctions between epithelial cells and it has functional groups for chemical modifications, which has resulted in a large.
Mucoadhesive systems offer a sustained drug release method, thus enhancing drug absorption in a sitespeci. University of baroda, fatehgunj, baroda390002, gujarat, india. These, however, do not always meet the exacting standards which modern manufacturing. Mucoadhesive microspheres of chitosan and polyvinyl alcohol as a carrier for intranasal delivery of insulin. Microspheres as a promising mucoadhesive drug delivery. Nl number of microspheres leached out in vitro drug release study1517 in vitro drug release studies were performed on the beads, using a dissolution apparatus uspxxiii, electro lab, mumbai.
Hiranandani college of pharmacy, ulhasnagar, maharashtra, india 2dept. Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at ph mucoadhesive properties. Examples of methods for preparation of mucoadhesive pellets and microspheres are extrusionspheronization 1, spraydrying 4, and emulsionsolvent evaporation 5. Chitosan was selected as a polymer in the preparation of mucoadhesive microspheres because of its good mucoadhesive and biodegradable properties. Effects of food intake on the mucoadhesive and gastroretentive properties of submicronsized chitosan coated liposomes. Mucoadhesive microspheres are one of the most promising novel techniques for drug delivery. Jan 22, 2014 contents of the powerpoint on formulation and evaluation of microspheres include. The release profile from the microspheres depends on the nature of the polymer used in the preparation as well as on the nature of the active drug. A strong interaction between chitosan microspheres and mucin was detected.
Formulation and evaluation of controlledrelease of. Combine multiple pdf files into one pdf, try foxit pdf merge tool online free and easy to use. Chitosan based microspheres of glibenclamide incorporated. The chitosan solutions were prepared in diluted acetic acid by stirring for 12 h and adjusting to ph 5. Transporting system of drug delivery in the body is an interesting as well as an wondered approach. Murthy pharmacy department, faculty of technology and engineering, m. Pegylated chitosan microspheres as mucoadhesive drug. The size distribution of microsphere was found to be good in both batches with drug polymer ratio 1. Mucoadhesive microspheres constitute an important part of these particulate drug delivery. Professor of pharmaceutics, new drug delivery systems laboratory, pharmacy department, donorsplaza, opp.
This webapp provides a simple way to merge pdf files. Strategies for improving ocular drug bioavailability and corneal. Natural and synthetic polymers assisted development of. Pdf formulation and evaluation of chitosan microspheres. Preparation and in vitro evaluation of mucoadhesive. The objective of the present study was to develop chitosan based mucoadhesive microspheres of clarithromycin to provide prolonged contact time for drug del. In this study, the mucoadhesive biopolymers of chitosan and its derivatives, including high molecular weight, low molecular weight, and carboxylic derivative, were employed as the excipients to prepare spraydried microspheres for the oromucosal drug e. In vivo results showed that there is remarkable increase in the bioavailability when venlafaxine was administered in the form of buccal mucoadhesive microspheres. Chitosan cs is a naturally occurring polymer which finds a wide array of pharmaceutical applications due to its low production costs, biodegradability, biocompatibility, nontoxic nature and mucoadhesion. Microspheres were pale yellow in color, freeflowing, spherical, and porous in outline. Formulation development and characterization of naproxen.
Formulation and invitro evaluation of chitosan based. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod. The effectiveness of the chitosan coated liposomes cslip was con. In turbidimetric titration, a polymer with high affinity to mucin forms aggregates easily, which can be quantitatively determined by light scattering at 600 nm a 600. Our result is supported by the report of chowdary and rao who used the microcapsules of glipizide with a coat consisting of alginate and a mucoadhesive polymer n sodium carboxymethyl cellulose, methyl cellulose, carbopol and hydroxypropyl methyl cellulose. Mucoadhesive microsphere as a drug delivery system. Drugs like proteins and peptides can also be targeted through this system. Soda pdf merge tool allows you to combine pdf files in seconds. Nps are mucoadhesive and safe as a microbicide carrier, the drawback of the cs nps is.
Mucoadhesive microspheres were formulated by emulsification solvent evaporation method using two polymers such as carbopol 974p, hpmc k100m. Microspheres prepared with gelatin as the polymer have been found to be highly mucoadhesive and have been used for the controlled release of many drugs. References powders and granulates freeflowing powders and granulates are needed for a variety of industrial processes. The different types are therapeutic magnetic microspheres and diagnostic microspheres. Spray dried mucoadhesive microspheres of ondansetron for. Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration s. Chitosan is a natural polycationic copolymer consisting of glucosamine and nacetylglucosamine units. Pdf mucoadhesive microspheres for controlled drug delivery. Rresearchesearch ppaperaper mucoadhesive chitosan microspheres for noninvasive. Mucoadhesive microspheres containing antihypertensive agent. The mucoadhesive properties of chitosan microspheres prepared by different method were evaluated by studying the interaction between mucin and microspheres in aqueous solution. Pdf influence of glutaraldehyde on drug release and. The microspheres exhibited good mucoadhesive property in the in vitro washoff test and also showed a high percentage drug entrapment efficiency.
Also, the article included different derivatives of chitosan and their use in different drug delivery system. Solid biodegradable microspheres incorporating a drug. Preparation of mucoadhesive microspheres the mucoadhesive microspheres were prepared by interpolymer complexation and solvent diffusion method. Mucoadhesive microspheres can provide the sustained release of drugs and advantage for pioglitazone hcl in the management of type2 diabetes with a high margin of safety and reduced side effects. The aim of this work was to design a controlledrelease drugdelivery system for the angiotensinii receptor antagonist drug telmisartan. These formulations also combine the advantages of solutions such as. Then drug and crosslinking agent were added in each chitosan solution to prepare a uniform dispersion. Formulation and evaluation of mucoadhesive microspheres of. Microspheres composed of hydroxypropyl methylcellulose h, chitosan cs, carbopol 934p cp and various combinations of these mucoadhesive polymers, and maltodextrin m, colloidal silicon dioxide a, and propylene glycol p as filler and shaper, were prepared by spraydrying technique. Mucoadhesive chitosan microspheres of carvedilol for nasal. Chitosanbased spraydried mucoadhesive microspheres for. The optimized formulations of microsphere using chitosan polymer, which showed the best results in terms of mucoadhesive properties were selected for in vivo study. The significantly higher time required by the thiolated chitosan microspheres to release acyclovir was due to its better stability in acidic medium, which contributed significantly less amount of drug release during initial 1 h of dissolution 29.
Development of mucoadhesive drug delivery systems by. In the formulation of chitosan microsphere an acidic environment is essentially required that may degrade acid sensitive moiety, peptide or protein drugs. Mucoadhesive drug delivery system linkedin slideshare. Formulation and invitro evaluation of chitosan based omeprazole mucoadhesive buccal tablets amit e. The present study aims to provide an overview of various aspects of mucoadhesive microsphere based on various polymers, methodology of preparation of. Gastroretentive floating and mucoadhesive drug delivery. The microspheres were prepared by emulsificationcrosslinking method and evaluated for size, shape, entrapment efficiency ee, in vitro mucoadhesion, in vitro drug. E4955 february 2005 with 294 reads how we measure reads. A 3 2 full factorial design was employed to study the effect of independent variables, polymertodrug ratio x 1, and stirring speed x 2 on dependent variables percentage mucoadhesion, t 80. The results of the washoff test indicated that the microspheres had fairly good mucoadhesive properties. Microspheres prepared were found discrete, spherical and free flowing. Medical university chennai 600032 in partial fulfillment of the requirements for the award of degree of master of pharmacy in pharmaceutics submitted by. Formulation and in vitro characterisation of glipizide loaded mucoadhesive gelatin microspheres a dissertation submitted to the tamilnadu dr.
Mucoadhesive microspheres for controlled drug delivery. The study aims to enhance the systemic drug absorption via the nasal membrane and to further. Merge pdf online combine pdf files for free foxit software. Mucoadhesive drug delivery system is a part of controlled delivery system. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. Insulin loaded microspheres was developed from varying ratio of chitosan solutions along with polyvinyl alcohol pva as additive polymer using spray drying method. Formulation of mucoadhesive microspheres of piroxicam. Protective effects of alginatechitosan microspheres loaded.
In vivo testing of the mucoadhesive microspheres to albino wistar rats demonstrated significant hypoglycemic effect of glipizide. Microspheres are manufactured in both solid and hollow form. Such materials can be incorporated in formulations to retain the dosage form at the absorbing epithelial membrane, thereby prolonging drug release and thus decreasing dosage frequency when compared to a more conventional dosage form. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products. Department of pharmaceutics, ezhuthachan college of pharmaceutical sciences, neyyattinkara695124, tvm, kerala, india. Comparisonof emulsification and ionic gelation method of. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains poorly defined.
Mucoadhesive microspheres as carriers in drug delivery. The microsphere of chitosan imparted good flow ability in comparision with. The rationale of developing mucoadhesive microspheres are that the formulation will be confined on a biological surface for localized drug delivery and the drug will be released close to the site of action with a consequent enhancement of bioavailability. Vara lakshmi faculty of pharmaceutical sciences, rajiv gandhi college of pharmacy, rajahmundry, east godavari, andhra pradesh, india. Microspheres based drug delivery system has received a wide appreciation due to its flexibility, cost effectiveness and broad regulatory acceptance. A free and open source software to merge, split, rotate and extract pages from pdf files. Preparation and evaluation of the in vitro drug release. Hence, there is a need to develop an oral drugdelivery system that is convenient for patients. Preparation and characterization of mucoadhesive microspheres. Preparation and characterization of bsaloaded chitosan. Mucoadhesion is a topic of current interest in the design of drug delivery systems.
Facile control of the ph of the mucin and mucoadhesive polymer solutions is one advantage of the turbidimetric titration method. Mucoadhesive microparticle of carboxymethyl chitosan was designed and. Microspheres prepared from admixtures of gelatin and crosslinked chitosan demonstrated some advantage over that prepared from gelatin alone in terms of better controlled release rate of cemetidine. The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. Formulation and in vitro characterization of intranasal mucoadhesive microspheres of lamotrigine using chitosan by gluteraldehyde cross linkingcorresponding author. This can be achieved by coupling bioadhesion characteristics to microspheres and developing mucoadhesive microspheres. The literature survey revealed scanty research on mucoadhesive microspheres of pioglitazone, which were. The mucoadhesive microspheres were discrete and free flowing.
The strategies studied to overcome such obstacles include the employment of the materials that,possibly, combine. Bioadhesives can be defined as natural or synthetic materials capable of adhering to a biological substrate. The aim of this study was to investigate the capabilities of chitosan microspheres as drug carrier system in coformulation with polyvinyl alcohol pva, to improve the systemic absorption of intranasal insulin delivery. Protective effects of alginatechitosan microspheres loaded with alkaloids from coptis chinensis franch. Chitosanbased mucoadhesive microspheres of clarithromycin. The microspheres contained amoxicillin, an antibacterial agent useful for the eradication of helicobacter pylori. Chitosanbased particles as controlled drug delivery systems. This research was aimed to evaluate a novel approach for preparation of mucoadhesive microspheres which can reside in the gastrointestinal tract for an extended time period. So to provide prolonged action glipizide microspheres were prepared by ionic gelation technique using different concentration of mucoadhesive polymers. In the present research work mucoadhesive microspheres of cimetidine was prepared using ionotropic gelation technique. Chitosan loaded mucoadhesive microspheres of glipizide for.
To avoid the firstpass metabolism of the drug lurasidone hcl and further improving its contact time with the nasal mucosa, intranasal mucoadhesive microspheres were developed by using natural chitosan and synthetic eudragit l 100 polymers by spraydrying method. In vitro evaluation of the mucoadhesive properties of chitosan. Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres. Formulation and characterization of polycarbophil coated. The present study describes two simultaneous approaches to improve its bioavailability, complexation of rhcl with cyclodextrins, and formulation of mucoadhesive microspheres of the complex using different proportions of carbopol and hpmc. This free online tool allows to combine multiple pdf or image files into a single pdf document. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. Unsurprisingly, the strongest mucoadhesive force would be generated for those microspheres containing 90% ww of chitosan, and the greatest gnp retention rates were 65. In vivo, in vitro evaluation of linseed mucilage based. It is used to deliver chemotherapeutic agent to liver tumor.
The cross linking polymer sodium alginate and mucoadhesive polymer were soaked in the water for 24 hours. Acyclovirloaded mucoadhesive microspheres using gum tragacanth as a mucoadhesive polymer and barium chloride as crosslinker were prepared for the. Microspheres were prepared by the emulsification crosslinking. The mucoadhesive microspheres of pioglitazone hydrochloride were formulated by orifice ion gelation technique using sodium alginate as a cell forming polymer and by using a natural bioadhesive polymer viz. The percent swelling of different microsphere formulation was found to follow the rank order 248 18%, 198 15%, 279 26% and 164 15%, respectively. Introduction since the early 1980,the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. Mucoadhesive chitosan microspheres for noninvasive and. The interaction was determined by the measurement of mucin adsorbed on the microspheres.
This work focused on the development of mucoadhesive and floating chitosan coated alginate beads as a gastroretensive delivery vehicle for amoxicillin, towards the effective eradication of helicobacter pylori, a major causative agent of peptic ulcers. Formulation and evaluation of mucoadhesive microspheres of propranolol hydrochloride for sustained drug delivery akash yadav and dinesh kumar jain department of pharmaceutics, college of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh452012, india. Pdf merge combine pdf files free tool to merge pdf online. This pdf is available for free download from a site hosted by medknow publications. The aim of the present study was to develop and characterize chitosan mucoadhesive microspheres of carvedilol crv for nasal delivery to improve bioavailability for treatment of hypertension and angina pectoris. Bioadhesive microspheres for bioavailability enhancement of.
Formulation and evaluation of chitosan microspheres containing isoniazid article pdf available in indian journal of pharmaceutical sciences 656. Turbidimetric titration method was used to compare the mucoadhesive properties of the polymers. The physiochemical characteristics of the prepared mucoadhesive microspheres of simvastatin are shown in table no 3. Mucoadhesive microspheres are anticipated to take up water from the underlying mucosal tissue by absorbing, swelling, and capillary effects, leading to considerable stronger adhesion.
Mucoadhesive and floating chitosancoated alginate beads. Gastroretentive floating and mucoadhesive drug delivery systems insights and current applications anita ayre1, neha dand2, k. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. Chitosan based mucoadhesive microspheres of clarithromycin as a delivery system for antibiotic to stomach volume. Mucoadhesive microspheres bioadhesion controlled drug delivery the oral route of drug administration constitutes the most convenient and preferred means of drug delivery to systemic circulation of body but has short gastrointestinal tract. Formulation and evaluation of mucoadhesive glipizide microspheres. For the preparation of microspheres, 1%3% wv solutions of chitosan were prepared in acetic acid. Pdf mucoadhesive microspheres of chitosan and polyvinyl. The yield of mucoadhesive microspheres was in the range of 81. How to merge pdfs and combine pdf files adobe acrobat dc. Easily combine multiple files into one pdf document. Gastroretentive floating microspheres are lowdensity systems that have. Mucoadhesive microspheres of chitosan and polyvinyl. Formulation and evaluation of mucoadhesive glipizide microspheres article pdf available in aaps pharmscitech 61.
Natural polymer based mucoadhesive hydrogel beads of. Effect of chitosan molecular weight and composition on. Formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method k. Preparation of mucoadhesive microspheres of atenolol by. Microspheres were prepared by ionic gelation technique using sodium alginate, carbopol 974, and hydroxyl propyl methyl cellulose k15 m hpmc as a mucoadhesive polymers. The purpose of this research was to prepare spraydried mucoadhesive microspheres for nasal delivery. Mucoadhesive microspheres for gastroretentive delivery of. Formulation and evaluation of mucoadhesive glipizide. Zuojin pill against ethanolinduced acute gastric mucosal injury in rats qiangsong wang,1,2, xiaoning zhu,1, hengli jiang,1, guifang wang,3 yuanlu cui1 1tianjin state key laboratory of modern chinese medicine, research center of traditional. The results demonstrated that spray drying is a suitable technique for preparation of buccal mucoadhesive microspheres of venlafaxine based on linseed mucilage. Mucoadhesive microspheres phd thesis proposal best essay. Spray drying tenofovir loaded mucoadhesive and phsensitive microspheres. Glipizide is an oral hypoglycemic drug with short halflife.
Crosslinked chitosan based stomach specific mucoadhesive. Telmisartan was encapsulated with different eudragit polymers by an emulsion solvent evaporation technique and the physicochemical properties of the formulations were characterized. Mahdollistaa yhdistaa pdf tiedostoja helposti vetamalla ja pudottamalla kayttoliittyma. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved andor better therapeutic performance of drugs.